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Two years ago, when I started researching NAD+ supplements, I found a troubling pattern: formulas with 25-30 ingredients where each carried doses so low that none reached the efficacy threshold. It was like trying to fill a bathtub with 30 different droppers instead of turning on the tap.
The food supplement industry has an ingredient overdose problem. More isn't better when each component carries 20mg of something you need 300mg of to work. That's why Vitalis Renew has exactly 6 active ingredients, each at the dose that scientific literature establishes, not the dose that allows cramming 24 more things onto the label.
In this article, you'll understand the logic behind each of those 6 components, why they're at these specific doses, and why adding more ingredients would have been a strategic and biological mistake.
A formula is not measured by how many ingredients it has, but by how many work at the correct dose
The 6 Components and Their Rationale
- Nicotinamide Riboside 300mg: maximum legal EU dose, direct NAD+ precursor
- Trans-Resveratrol 150mg + Pterostilbene 50mg: activate sirtuins (longevity genes), complementary bioavailability
- TMG 500mg: obligatory methyl donor when using NR (protects methylation reserves)
- Spermidine 3mg: activates autophagy (cellular recycling), dose backed by human studies
- Hydroxytyrosol 25mg: blocks AGE formation (glycosylated ageing proteins)
- Zero filler: no maltodextrin, no superfluous excipients, no decorative doses
What is Vitalis Renew and What's It For
Vitalis Renew is a morning cellular renewal food supplement designed to elevate NAD+, activate sirtuins and stimulate autophagy in people aged 35-60 who are beginning to notice declining energy, slower recovery and accelerated ageing markers.
It's not a multivitamin. It's not a nootropic. It's a specific protocol for three biological ageing mechanisms that share a common window of action: the morning, on an empty stomach.
The formulation is based on a simple principle: if an ingredient doesn't reach the minimum effective dose demonstrated in studies, it doesn't go in. That's why it has 6 components instead of 30.
How Each of the 6 Ingredients Works
Nicotinamide Riboside (NR): The Most Effective NAD+ Precursor
NAD+ is a coenzyme present in every cell in your body that declines by 50% between ages 40 and 60. Without sufficient NAD+, mitochondria don't produce energy effectively and sirtuins (repair proteins) don't function.
Nicotinamide Riboside is the NAD+ precursor with the best efficacy and safety profile. Meta-analyses published in Nature Aging show that 300mg daily elevates blood NAD+ by 40-90% in 2-4 weeks.
Why exactly 300mg? Because it's the maximum dose allowed in the EU following EFSA approval. Studies with higher doses (500-1000mg) show marginal additional improvements, but aren't authorised in Europe.
TMG (Trimethylglycine): The Ingredient Nobody Tells You About
Here comes the part most NAD+ formulas ignore: taking NR consumes methyl groups from your body through the methylation pathway. If we don't replenish those methyl groups, we can create one problem whilst solving another.
TMG (also called betaine) is a direct methyl donor that restores the reserves that NR consumes. Studies in Cell Metabolism demonstrate that combining NR + TMG prevents hypomethylation and improves cardiovascular markers.
Dose: 500mg, the same amount used in NR+TMG combination studies.
Trans-Resveratrol + Pterostilbene: The Sirtuin Duo
Sirtuins are proteins that depend on NAD+ to repair DNA, regulate metabolism and activate longevity genes. Elevating NAD+ without activating sirtuins is like having petrol in the tank but not turning the key.
Trans-resveratrol (150mg) activates SIRT1, the most-studied sirtuin. The problem: it has poor oral bioavailability. That's why we add pterostilbene (50mg), a methylated analogue of resveratrol with 4 times greater bioavailability.
Studies in the Journal of Clinical Endocrinology show that the resveratrol + pterostilbene combination produces synergistic SIRT1 activation superior to each one separately.
Spermidine: The Autophagy Activator
Autophagy is the process by which cells recycle damaged components (defective organelles, misfolded proteins, dysfunctional mitochondria). It declines with age, and its deterioration is associated with neurodegeneration and sarcopenia.
Spermidine is a natural polyamine that activates autophagy through acetyl inhibition. Meta-analyses in Nature Medicine link high spermidine intake with a 15% reduction in cardiovascular mortality.
Dose: 3mg daily, the amount used in the SMARTAGE study (a human trial on memory and longevity). Many formulas carry 1mg, which is insufficient according to the literature.
Hydroxytyrosol: The Olive Oil Anti-AGE Agent
AGEs (advanced glycation end products) are proteins or lipids that react with sugars and become rigid and dysfunctional. They accumulate with age in skin, arteries, kidneys and brain.
Hydroxytyrosol, a polyphenol from extra virgin olive oil, blocks AGE formation and increases the expression of antioxidant enzymes. Studies in Free Radical Biology and Medicine show reduced oxidative stress markers with 25mg daily.
Dose: 25mg, equivalent to about 50ml of high-quality extra virgin olive oil (a quantity difficult to consume daily with optimal bioavailability).
Why More Ingredients Would Have Been Worse
The temptation in formulation is to add "a bit of everything": CoQ10, quercetin, PQQ, alpha-lipoic acid, astaxanthin... The problem is mathematical and biological.
Mathematical problem: a standard capsule contains 500-800mg of powder. If you put in 15 ingredients, each one carries ~40mg. Most need 100-500mg to reach effective doses.
Biological problem: NAD+, sirtuins and autophagy share an activation window (morning, fasted). Adding ingredients with other optimal windows (e.g. melatonin, which is nocturnal) dilutes the focus without adding benefit.
Regulatory problem: AESAN is strict with claims. Each additional ingredient adds risk of discrepancy between dose and permitted claim.
That's why Longevitalis 3 Products Philosophy explains our thinking: depth over breadth, dose over variety.
How to Choose an NAD+ Supplement That Works
Most NAD+ supplements on the market fail in one or more of these criteria:
- Insufficient NR dose: many carry 100-150mg when you need 300mg
- No TMG: they raise your NAD+ but lower methylation (ignored problem)
- Resveratrol without pterostilbene: poor bioavailability, questionable efficacy
- Decorative spermidine: 0.5-1mg instead of the 3mg from studies
- Maltodextrin or excipient filler: up to 40% of capsule weight can be inert
Vitalis Renew is the first complete NAD+ protocol legal in the EU. It combines Nicotinamide Riboside (300mg, maximum permitted dose), trans-resveratrol and pterostilbene (sirtuins), TMG (obligatory methyl donor with NR), spermidine (autophagy) and hydroxytyrosol (anti-AGEs).
Formulated in Spain under GMP certification, with purity controls on every batch. No maltodextrin, no magnesium stearate, no titanium dioxide. Just the 6 actives at effective doses.
Recommended Dosage and Optimal Timing
Dosing is straightforward: 2 capsules in the morning, on an empty stomach, 20-30 minutes before breakfast.
Why on an empty stomach? Three reasons:
- NAD+ and fasting are synergistic: fasting activates AMPK, which works in tandem with sirtuins
- NR bioavailability: studies show 30% superior absorption on an empty stomach
- Autophagy: spermidine potentiates autophagy, a process that peaks during the overnight fast and early morning hours
If you train fasted in the morning, take Vitalis Renew 30-45 minutes before training. The NAD+ peak coincides with peak mitochondrial demand.
Side Effects and Contraindications
The 6 ingredients in Vitalis Renew have a robust safety profile at the doses used. Side effects reported in studies:
- NR: occasionally mild nausea in first doses (disappears in 3-5 days)
- Resveratrol/Pterostilbene: rarely mild digestive discomfort
- TMG: can alter body odour at doses >1g/day (we use 500mg)
- Spermidine: no adverse effects reported at doses <5mg
- Hydroxytyrosol: excellent tolerance, component of Mediterranean diet
Contraindications:
- Pregnancy and lactation (lack of specific evidence)
- Under 18 years old (not target population)
- People with coagulation disorders (resveratrol has slight antiplatelet effect)
- If you take anticoagulants (warfarin, acenocoumarol), consult your doctor
NAD+ supplements can interact with medication metabolised by cytochrome P450. If you take chronic medication, consult your doctor before starting.
Frequently Asked Questions about Vitalis Renew
Can I take Vitalis Renew if I already take a multivitamin?
Yes, there's no overlap with standard multivitamins. NAD+, sirtuins and autophagy are specific pathways that multis don't cover. If your multi contains resveratrol, check the dose (most carry <50mg, insufficient).
How long until I notice effects?
Biomarkers (blood NAD+) rise in 2-4 weeks. Subjective effects (energy, recovery) appear between 3-6 weeks in 70% of users according to feedback. Deep cellular renewal is a months-long process, not days.
Can I combine it with LongeviNocturno?
Yes, and it's the most common combination. Vitalis Renew acts on daytime cellular renewal; LongeviNocturno optimises nighttime repair. They're complementary, with no ingredient or action window overlap.
Do I need to cycle (take breaks)?
There's no evidence indicating a need to cycle NR or sirtuins. The longest studies (12-18 months) show sustained benefits without plateau. You can take it continuously or take breaks by personal preference.
Is it safe for athletes?
All ingredients are legal in professional sport (don't appear on WADA list). In fact, studies in cyclists show NR improves mitochondrial efficiency and post-effort recovery.
What's the difference from NMN (Nicotinamide Mononucleotide)?
NMN isn't approved as a food supplement in the EU (only in the US and some Asian countries). NR is, and has more human safety studies. Both elevate NAD+, but only NR is legal here.
Conclusion: Less Is More (If You Know What to Put In)
When I started designing Vitalis Renew, the question wasn't "what trendy ingredients should I include?", but "what does the body need to renew itself at the cellular level and what dose does science indicate?".
The answer was 6 ingredients, not 30. Six molecules with clear mechanisms, demonstrated synergies and doses that work.
I can't promise you'll reverse 10 years in 3 months. I can tell you that every component is at the dose studies consider effective, there's no decorative filler, and the protocol makes biological sense.
The rest is up to you: consistency, quality sleep (how to sleep better if you need help), exercise and real food. Supplements are accelerators, not substitutes.
If you want to try Vitalis Renew, you'll find it here. If you prefer to research more, that's perfect too. In longevity, informed decisions always win.
Disclaimer: This information is for educational purposes and does not replace professional medical advice. Consult your doctor before starting any protocol, especially if you take medication or have pre-existing conditions. Vitalis Renew is a food supplement, not a medicine, and is not designed to diagnose, treat, cure or prevent any disease.
