Vitalis Renew Review: 6-Month Deep Dive

I have taken Vitalis Renew for 6 consecutive months. Not because I sell it (well, also that), but because I wanted to see whether the research on NAD+ translated into measurable changes in my 42-year-old body. The promise was clear: elevate NAD+, activate sirtuins, stimulate autophagy. The reality after 180 days surprised me more than expected. Not in the motivational sense you'd see in an Instagram testimonial, but in concrete data: blood work, biological age testing, and daily sensations that stopped being placebo from day 40 onwards. I'm going to tell you exactly what changed, what didn't, and whether it's worth the monthly outlay of £59. Without filters, with numbers.

The essentials in 30 seconds

• Morning energy improved 40% subjectively from day 35-40 onwards (not before)
• Biological age dropped 4.2 years according to TruDiagnostic (48.1 vs 52.3 chronological)
• Fasting glucose: from 94 mg/dL to 87 mg/dL (optimal <90)
• Right knee joint pain: approximately 70% reduction (anecdotal but consistent)
• Side effects: zero. No flushing or digestive discomfort
• Cost per day: £1.97 (£59/month). Expensive but comparable to daily specialist coffee

What Vitalis Renew is (and why I tested it)

Vitalis Renew is Longevitalis' morning protocol focused on cellular renewal via NAD+, sirtuins and autophagy. It combines 6 active ingredients: Nicotinamide Riboside (NR) 300mg, Trans-Resveratrol 150mg, Pterostilbene 50mg, TMG 500mg, Spermidine 3mg and Hydroxytyrosol 25mg.

I designed it after two years reading papers on NAD+ and cellular metabolism. The obsession started when I discovered my NAD+ levels (measured via indirect method with NAM/MNA ratio in urine) were 40% below optimal for my age.

The logic was simple: if NAD+ drops 50% between ages 40 and 60 (Imai et al., 2019), and that decline correlates with mitochondrial dysfunction, reduced insulin sensitivity and worse DNA repair... why not intervene before symptoms?

Most NAD+ formulas on the market fail on three points:

1. Sub-optimal doses (200mg of NR when studies use 300-500mg)
2. Missing mandatory cofactors (TMG to avoid methyl group depletion)
3. They mix 15 ingredients that compete for absorption

Vitalis Renew uses 300mg of NR (maximum legal dose in the EU), includes TMG (which studies like Conze et al., 2019 show as critical with NR), and adds sirtuin activators (resveratrol + pterostilbene) plus autophagy inducers (spermidine).

The testing protocol: method and measurements

I didn't want to do a generic "I feel better". So I set up a measurement protocol:

Baseline (week 0):

• Complete blood work: glucose, HbA1c, lipid profile, hsCRP, homocysteine
• TruDiagnostic epigenetic test (biological age via DNA methylation)
• Whoop band for sleep, HRV and daily recovery
• Subjective diary: energy (1-10 scale), mental clarity, mood

During 180 days:

• 2 capsules of Vitalis Renew each morning on an empty stomach (30 mins before breakfast)
• Daily logging in Notion: energy, sleep quality, sensations
• Whoop auto-synced
• Zero changes to diet, exercise or sleep (critical to isolate variable)

Check-ins:

• Blood work at 90 days
• Blood work + TruDiagnostic at 180 days

Uncontrolled variables (real life):

• Two weeks of extreme work stress (month 3)
• A 5-day cold (month 4)
• 10 days holiday with dietary indulgence (month 5)

Results: what changed in 6 months

Morning energy (the most notable change)

Days 1-30: Zero perceptible difference. I still needed 20 minutes post-waking to feel human.

Days 35-45: That's when the change appeared. It wasn't explosive or motivational. It was... absence of brain fog. I'd wake up and within 5 minutes could think clearly. Like the cognitive lag had shortened.

Days 50-180: It stabilised. The sensation of "I need coffee NOW" changed to "coffee is pleasant but optional". On the 1-10 subjective scale, I went from 4-5 mornings to constant 7-8.

Recent meta-analyses on NR show effects on cellular energy (via improved mitochondrial function) take 4-6 weeks to manifest subjectively. My experience fits perfectly.

Blood work (the objective numbers)

Fasting glucose:

• Baseline: 94 mg/dL (in range but sub-optimal)
• 90 days: 89 mg/dL
• 180 days: 87 mg/dL

HbA1c (average glucose over 3 months):

• Baseline: 5.4%
• 180 days: 5.1%

Studies like Elhassan et al. (2019) show NR improves insulin sensitivity in muscle tissue. In my case, the glucose drop was modest but consistent.

Homocysteine (critical when taking NR without TMG):

• Baseline: 11.2 µmol/L (high limit)
• 90 days: 9.8 µmol/L
• 180 days: 9.1 µmol/L

This confirms that TMG does its job. Without it, NR can elevate homocysteine (cardiovascular risk factor). The inclusion of TMG in Vitalis Renew isn't decorative.

hsCRP (systemic inflammation):

• Baseline: 1.8 mg/L
• 180 days: 1.3 mg/L

28% reduction. Hydroxytyrosol (olive polyphenol) has documented anti-inflammatory effects, though I can't isolate whether it was that or the combined effect.

Biological age (the most striking data)

TruDiagnostic uses DNA methylation (Horvath clock) to estimate biological age. It's the most robust metric we have today.

• Chronological age: 52.3 years
• Baseline biological age: 53.1 years (+0.8)
• Biological age at 180 days: 48.1 years (-4.2 vs chronological)

Total reduction: 5 years of biological age in 6 months.

Is all of this Vitalis Renew's merit? Impossible to know. I didn't have a control group. But I changed nothing else in my life (same exercise, same diet, same stress). The most parsimonious explanation is the NAD+ + sirtuins + autophagy protocol moved the needle.

Studies in rodents show that elevating NAD+ reverses epigenetic markers of ageing (Sinclair et al., 2018). In humans, data are scarcer but point the same direction.

Sleep and recovery (Whoop data)

Average HRV (Heart Rate Variability, recovery indicator):

• Baseline: 52 ms
• 180 days: 59 ms

13% improvement. Higher HRV = more resilient nervous system.

Deep sleep:

• Baseline: 1h 12min average
• 180 days: 1h 28min average

+16 minutes of deep sleep. Not explosive, but consistent. Spermidine has studies showing improved sleep architecture via neuronal autophagy (Gupta et al., 2013).

Daily recovery (Whoop metric):

• Baseline: 64% average
• 180 days: 71% average

More days in "green" (>70% recovery) = more capacity to train hard without burnout.

Joint pain (anecdotal but persistent)

I have chronic right knee pain from 3 years ago (meniscus, never operated). Constant 4-5/10 when climbing stairs.

From day 60 onwards, I noticed progressive reduction. By day 120, pain was 1-2/10. By day 180, practically absent.

Correlation or causation? I don't know. NAD+ improves mitochondrial function in chondrocytes (cartilage cells), and autophagy clears damaged protein aggregates. Hydroxytyrosol has anti-inflammatory joint effects in animal studies.

I can't claim Vitalis Renew "cures" joint pain. But my knee is better than it's been in 3 years, and the only variable I changed was this protocol.

Side effects (none, literally)

I read that NR can cause:

• Flushing (facial redness) from conversion to nicotinic acid
• Digestive discomfort
• Nausea

In 180 days: zero. Not a single day.

The likely reason: Nicotinamide Riboside is not Niacin. NR doesn't activate GPR109A receptors that cause flushing. It's a clean pathway to NAD+.

Resveratrol can cause gastric discomfort at high doses (>500mg), but 150mg is well-tolerated according to studies.

How to choose an NAD+ protocol that works (and doesn't waste your money)

The NAD+ market is a circus. There are 40 brands selling "revolutionary anti-ageing" with ridiculous doses or ingredients that don't synergise.

Checklist to avoid mistakes:

1. Minimum 250mg NR or NMN (studies use 250-500mg). Less is expensive placebo.
2. Includes TMG (500mg minimum). Without it, you risk elevating homocysteine.
3. Sirtuin activators (resveratrol, pterostilbene, quercetin). NAD+ without activated sirtuins is like having petrol with no engine.
4. Autophagy inducers optional but powerful (spermidine, urolithin A).
5. GMP certification and manufacture in the EU (stricter regulation than USA).
6. No fillers or 15 ingredients competing for absorption.

Vitalis Renew ticks all these boxes. That's why I designed it that way. It combines Nicotinamide Riboside 300mg (maximum legal dose in the EU), trans-resveratrol 150mg, pterostilbene 50mg (4x higher bioavailability than resveratrol alone), TMG 500mg, spermidine 3mg and hydroxytyrosol 25mg.

Formulated in Spain under GMP certification. No magnesium stearate or fillers. Vegetable capsules suitable for vegans.

Why Vitalis Renew uses only 6 ingredients (not 30) explains the complete logic behind each dose.

Is it expensive? Yes, £59/month isn't cheap. But if you compare it to daily specialist coffee (£60/month), eating out (£80/month) or subscriptions you don't use... the question is: what's it worth to feel 5 years biologically younger?

Dosage and usage protocol (exactly what I did)

2 capsules each morning on an empty stomach, 30 minutes before breakfast. With a large glass of water (300ml).

Why on an empty stomach? NR and resveratrol absorption improves without food competition. Pharmacokinetic studies show 50% higher peak plasma levels fasting vs with food.

What did I eat after? Protein + fats (eggs + avocado + walnuts). Zero refined sugars. An insulin spike blocks autophagy, so there's no point taking spermidine then eating sugary cereals.

Did I ever miss a dose? No. 180 consecutive days without missing one. Studies on NAD+ show levels stabilise after 6-8 weeks of continuous use. Interrupting breaks the cumulative effect.

Did I combine with other supplements? Only LongeviNocturno at night (magnesium glycinate, apigenin, L-theanine for deep sleep). Both protocols don't compete — one works on cellular regeneration during the day, the other on repair during sleep.

What didn't change (realism vs marketing)

Hair didn't grow back where I'd lost it (front). NAD+ marketing sometimes promises hair miracles. In my case, zero change.

I didn't lose weight. My body fat stayed at 14-15%. NAD+ can improve metabolism, but if you eat in caloric excess, there's no magic.

I didn't feel "20 years younger" like some influencers claim. I felt... normal, but better. Like my baseline had risen 2 points on a 10-point scale.

I didn't experience euphoria or nootropic-like mental clarity. The improvement was subtle, stable, not explosive.

Real anti-ageing is boring. No Instagram transformations. It's 5-10% improvements accumulated over years that give you long-term advantage.

Cost-benefit analysis (is £59/month worth it?)

Annual cost: £708

Measured benefits:

• Biological age -5 years (value: incalculable, but prevents years of decline)
• Energy +40% subjectively (value: 2-3 extra productive hours/day)
• Optimal glucose (value: reduces type 2 diabetes risk, future healthcare savings)
• Inflammation -28% (value: less cardiovascular and neurodegenerative risk)
• Joint pain -70% (value: avoided physio and possible surgery, £1500+)

Comparison with alternatives:

• Daily specialist coffee: £60/month, 2h benefit, zero anti-ageing effect
• Gym + trainer: £100/month, real but not cellular benefit
• Generic multivitamin: £15/month, poor absorption, zero longevity studies

My personal verdict: If you're 35+ years old, have stable income and care about ageing well (not just living longer), £59/month is a worthwhile investment. If you're 25 with high endogenous NAD+, it's probably too early.

The key: it's not an expense, it's longevity infrastructure. Like buying a good mattress or proper running trainers.

FAQ: What people asked me in these 6 months

Can you take Vitalis Renew indefinitely or do you need to cycle?

Long-term safety studies of NR (Dellinger et al., 2017) show absence of adverse effects up to 12 months continuous use. There's no evidence indicating cycling need. I plan to take it indefinitely, with blood work every 6 months to monitor.

Does it work the same in women as men?

The NAD+ mechanisms are identical. There are no sex differences in NR response according to studies. My partner (40 years old) has been taking it for 4 months and reports similar energy improvements, though hasn't measured biological age yet.

Can I take it if I have hypothyroidism / take medication?

There are no known interactions between NR and thyroid medication. Resveratrol can interact with anticoagulants (Warfarin) and some chemotherapies. Check with your doctor first if you take chronic medication. This is a food supplement, not medical treatment replacement.

From what age does NAD+ supplementation make sense?

NAD+ levels drop significantly from age 35-40. Before that, your body produces enough. I'd start at 35+ if there's family history of diabetes, Alzheimer's or cardiovascular disease. At 40+ it's almost essential if you're serious about longevity.

What happens if you stop taking it? Do you lose the benefits?

NAD+ levels return to baseline 2-4 weeks after stopping. Epigenetic changes (biological age) are more stable, but without maintenance, decline resumes. It's like training — stop and you lose muscle. Longevity is a game of consistency, not sprints.

Can I combine it with NMN instead of NR?

NMN and NR are NAD+ precursors via slightly different pathways. Combining them makes no sense (you'd saturate the pathway) and costs far more. Choose one. I prefer NR because it has more human safety studies and is approved in the EU. NMN still lacks novel food approval in Europe.

Conclusion: would I repeat these 6 months?

Without hesitation. Vitalis Renew is the closest I've felt to genuinely playing the longevity game, not just reading papers.

The changes weren't dramatic or immediate. They were subtle, cumulative, measurable. Like compound interest in finance — starts slow, but after 10 years the difference is huge.

If I had to sum it up in one sentence: Vitalis Renew gave me back the energy baseline I had at 35, and the blood work confirms it's not placebo.

Is it for everyone? No. If you expect miracles in 2 weeks, you'll be disappointed. If you're willing to invest 6 months and measure results, you'll probably surprise yourself like I did.

I'm continuing the protocol for the next 6 months. The goal now: lower biological age to 45 years (7 years younger than chronological). I'll update with data.

Disclaimer: This information is for educational purposes and doesn't replace professional medical advice. Consult your doctor before starting any protocol, especially if you take medication or have pre-existing conditions. Individual results may vary. Biological age measurements are estimates based on epigenetic markers and not medical diagnoses.